Issues of regionalism in international law have recently gained renewed significance. The article examines the problem of a fundamental shift in international politics, manifested in the reorientation of state priorities and the movement away from active participation in universal processes toward the persistent creation of various forms of regional cooperation. In a multipolar environment, regionalism is gaining the status of one of the most effective instruments for solving political, economic, and legal challenges, compensating for the declining effectiveness of universal international mechanisms. Particular attention is paid to the concept of “normative regionalism” proposed by the International Law Commission, which presupposes either the existence of special norms or principles (lex specialis) binding upon the member states of regional integration organizations, or the non-application of universal norms or principles to those states. It is noted that the practice of implementing the UN Charter has, in effect, strengthened the role of regional structures, including their participation in the maintenance of international peace and security.